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Published on: August 1, 2018
Efficient solid-phase synthesis of sulfotyrosine peptides using a sulfate protecting-group strategy
1Department of Chemistry, University of Waterloo, 200 University Ave. West, Waterloo, Ontario, N2L 3G1, Canada.
Abstract:
Double protection: Efficient Fmoc-based solid-phase synthesis (SPPS) of sulfotyrosine (sY) peptides is achieved by incorporating the sY residue(s) as a dichlorovinyl-protected (DCV) sulfodiester(s) and using 2-methylpiperidine for Fmoc removal. After removal of the other protecting groups, the DCV group could be cleaved by mild hydrogenolysis giving the sY peptides in good yield.
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