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Polymorphic drug metabolizing CYP-enzymes--a pathogenic factor in oral lichen planus?

C Kragelund1, C Hansen, J Reibel

  • 1Section of Oral Medicine, Clinical Oral Physiology, Oral Pathology & Anatomy, Department of Odontology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. ckr@odont.ku.dk

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
|February 5, 2009
PubMed
Summary

This study investigated if genetic variations in cytochrome P450 enzymes (CYPs) contribute to oral lichen planus (OLP). While no link was found to poor metabolism, a specific CYP2D6 variant was more common in OLP patients, suggesting molecular mimicry may play a role.

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