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Updated: Jun 25, 2026
06:07
Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
Published on: October 22, 2020
[Smoking and lung cancer: attributable risks according to gender]
Marcia Erazo B1, Hugo Amigo C, Manuel Oyarzún G
1Programa de Doctorado en Salud Pública, Universidad de Chile, Santiago, Chile. merazo@med.uchile.cl
Revista Medica De Chile
|February 6, 2009
Summary
Smoking significantly increases lung cancer risk, with high attributable fractions in both men and women. This study quantizes the population burden, estimating thousands of smoking-related lung cancer cases annually.
Area of Science:
- Epidemiology
- Public Health
- Oncology
Background:
- The link between smoking and lung cancer is established, but data on attributable risk and population burden is limited.
- Understanding these metrics is crucial for public health interventions and resource allocation.
Purpose of the Study:
- To quantify the attributable risk and population attributable risk of smoking in lung cancer patients.
- Focus on patients receiving care within Santiago's Public Health Services.
Main Methods:
- A case-control study design, matched by age, was employed.
- Crude and adjusted attributable risks and population attributable risks were calculated.
- Potential confounders and interaction variables were controlled for.
Main Results:
- Lung cancer patients exhibited significantly higher smoking prevalence compared to controls (women: 64.5% vs 39.7%; men: 95.8% vs 67.1%).
- Attributable risks were substantial: 64.4% for women and 90.4% for men.
- Population attributable fractions were 41.9% for women and 86.3% for men, projecting to ~1975 annual smoking-attributable lung cancer cases in Chile.
Conclusions:
- Smoking poses a high and statistically significant risk for lung cancer.
- These risks remain significant even after adjusting for confounding factors.
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