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Related Experiment Video

Updated: Jun 25, 2026

Inducing Apical Periodontitis in Mice
10:26

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

Interleukin-1 polymorphisms in relation to external apical root resorption (EARR).

Norbert Gülden1, Thomas Eggermann, Klaus Zerres

  • 1Department of Orthodontics, RWTH Aachen University, Aachen, Germany. nguelden@ukaachen.de

Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopadie : Organ/Official Journal Deutsche Gesellschaft Fur Kieferorthopadie
|February 6, 2009
PubMed
Summary

Genetic predisposition for External Apical Root Resorption (EARR) was investigated. The IL-1A genotype 2-2 was significantly associated with EARR, suggesting its role in root resorption risk.

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Last Updated: Jun 25, 2026

Inducing Apical Periodontitis in Mice
10:26

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

Area of Science:

  • Genetics
  • Orthodontics
  • Periodontology

Background:

  • Genetic factors are increasingly recognized in root resorption.
  • External Apical Root Resorption (EARR) is a concern in orthodontics.
  • Interleukin gene polymorphisms are potential candidates for genetic predisposition.

Purpose of the Study:

  • To investigate the association between EARR phenotype and specific gene polymorphisms.
  • To explore the role of IL-1A and IL-1B gene variations in EARR.
  • To assess genetic predisposition for root resorption.

Main Methods:

  • Orthopantomograms (OPG) of EARR patients (n=96) and controls (n=162) were analyzed.
  • Genotyping for IL-1A (-889) and IL-1B (+3954) polymorphisms was performed on a subgroup of EARR patients (n=49).
  • Statistical analysis compared genotype distributions and assessed resorption extent.

Main Results:

  • A significant association was found between the IL-1A genotype 2-2 and EARR.
  • The IL-1A genotype 2-2 correlated with the extent of root resorption.
  • No significant association was observed for IL-1B polymorphism in EARR patients compared to controls.

Conclusions:

  • The IL-1A genotype 2-2 appears to be a predisposing factor for EARR.
  • IL-1B polymorphism did not show a predisposition for sporadic EARR in this cohort.
  • These findings provide a basis for genetic risk assessment in pre-orthodontic evaluations.