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Published on: April 24, 2020
Long axial length as risk factor for normal tension glaucoma
Yoshiko Oku1, Hidehiro Oku, Masami Park
1Sensho-kai Eye Institute, Iseda-cho, Uji, Kyoto, Japan.
Summary
Longer eye axial length is a significant risk factor for normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG). Patients with longer axial lengths require careful glaucoma screening.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Ocular Biometry
Background:
- Normal tension glaucoma (NTG) is highly prevalent in Japanese populations, necessitating screening beyond intraocular pressure (IOP) measurements.
- This study investigated the association between ocular axial length and the presence of NTG.
Purpose of the Study:
- To determine if axial length is a significant risk factor for normal tension glaucoma (NTG).
- To explore the relationship between axial length and primary open-angle glaucoma (POAG).
Main Methods:
- Retrospective review of medical records for 87 NTG patients, 137 POAG patients, and 978 controls undergoing cataract or glaucoma surgery.
- Analysis of axial length, IOP, corneal curvature, age, and gender using logistic regression and Kruskal-Wallis/Mann-Whitney U tests.
Main Results:
- Axial length showed a significant association with both NTG (odds=1.24) and POAG (odds=1.28).
- Higher incidence of NTG or POAG was observed in individuals with axial lengths ≥25.0 mm (odds=2.29).
- Men exhibited significantly longer axial lengths than women; age correlated negatively with axial length.
Conclusions:
- Increased ocular axial length is a confirmed risk factor for both NTG and POAG.
- Individuals with longer axial lengths warrant meticulous glaucoma examination.
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