Related Experiment Video
Updated: Jun 3, 2025
10:10
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
Published on: February 15, 2022
1.3K
Diabetes Mellitus: A Risk Factor in Schlemm's Canal-Based Minimally Invasive Glaucoma Surgery.
Etsuo Chihara1, Eri Nakano2, Tomoyuki Chihara1
1Sensho-kai Eye Institute, Minamiyama 50-1, Iseda, Kyoto 611-0043, Japan.
Journal of Clinical Medicine
|January 8, 2025
Summary
Diabetes mellitus (DM) negatively impacts outcomes for Schlemm's canal-based minimally invasive glaucoma surgery (MIGS). Diabetic patients experienced higher postoperative intraocular pressure (IOP) and reduced success rates compared to non-diabetic individuals.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Surgical Outcomes
Background:
- Minimally invasive glaucoma surgery (MIGS) targeting Schlemm's canal is a common treatment for glaucoma.
- The influence of diabetes mellitus (DM) on the long-term efficacy of these procedures is not fully understood.
Purpose of the Study:
- To investigate the effect of diabetes mellitus (DM) on the outcomes of Schlemm's canal-based MIGS.
- To compare postoperative intraocular pressure (IOP) and surgical success rates between diabetic and non-diabetic glaucoma patients.
Main Methods:
- Retrospective cohort study analyzing 109 patients (25 diabetic, 84 non-diabetic) with primary open-angle glaucoma or ocular hypertension.
- Postoperative IOP, intracameral bleeding, and long-term IOP control were assessed over a mean follow-up of 35.3 months.
Main Results:
- No significant difference in preoperative IOP between diabetic and non-diabetic groups.
- Diabetic patients showed significantly higher postoperative IOP from 3 months to 2 years (p=0.019 to 0.001).
- Lower 3-year IOP control rates (≤15 mmHg: 17.8% vs 30.4%, p=0.042; ≤18 mmHg: 56.7% vs 79.5%, p=0.065) were observed in diabetic patients. DM was a significant risk factor for higher postoperative IOP at 6 and 12 months (p<0.001).
Conclusions:
- Diabetes mellitus is a significant risk factor for suboptimal outcomes in Schlemm's canal-based MIGS.
- Diabetic patients are less likely to achieve target IOP levels after this type of glaucoma surgery.
- Further research may be needed to optimize MIGS strategies for diabetic glaucoma patients.
Related Concept Videos
01:25Glaucoma: Overview
502
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
502
01:28Angle Closure Glaucoma: Treatment
434
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
434
01:27Open Angle Glaucoma: Treatment
391
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
391