Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

454
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
454
Glaucoma: Overview01:25

Glaucoma: Overview

528
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
528
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

408
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
408

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive, High-Spatiotemporal-Resolution Intravital Two-Photon Imaging of the Mouse Conventional Outflow Pathway: Green Intravital Imaging.

Investigative ophthalmology & visual science·2026
Same author

Extrusion-Free Survival Following Glaucoma Drainage Device Surgery Using EverPatch Plus<sup>®</sup>: A Propensity Score-Weighted Survival Analysis.

Journal of clinical medicine·2026
Same author

Correlation between mid-term intraocular pressure and aqueous flare value in micropulse transscleral cyclophotocoagulation: a retrospective observational study.

BMC ophthalmology·2026
Same author

Possible Effects of Topical Rho-Kinase Inhibitor on Schlemm's Canal Morphology Parameters.

Biomedicines·2026
Same author

Interaction of Myopic Optic Neuropathy (MON) and Glaucomatous Optic Neuropathy (GON): Pathophysiology and Clinical Implications.

Journal of clinical medicine·2026
Same author

Clinical Debates in Minimally Invasive Glaucoma Surgeries (MIGSs).

Journal of clinical medicine·2026

Related Experiment Video

Updated: Jun 14, 2025

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.4K

Historical and Contemporary Debates in Schlemm's Canal-Based MIGS.

Etsuo Chihara1, Teruhiko Hamanaka2

  • 1Sensho-Kai Eye Institute, Minamiyama 50-1, Iseda, Kyoto 611-0043, Japan.

Journal of Clinical Medicine
|August 29, 2024
PubMed
Summary

Minimally invasive glaucoma surgery (MIGS) shows promise for reducing eye pressure and preserving vision. However, further histopathological research is needed to fully understand wound healing and optimize surgical outcomes for glaucoma patients.

Keywords:
Kahook dual bladeSchlemm’s canal opening surgeryT hookTanito micro-hookcanaloplastyhistoryminimally invasive glaucoma surgery (MIGS)surgical successtrabectometrabeculectomytrabeculotomy

More Related Videos

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

10.4K
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.0K

Related Experiment Videos

Last Updated: Jun 14, 2025

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.4K
A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

10.4K
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.0K

Area of Science:

  • Ophthalmology
  • Surgical Innovation

Background:

  • Glaucoma is a leading cause of global blindness.
  • Minimally invasive glaucoma surgery (MIGS) is increasingly used for mild to moderate cases.
  • MIGS offers efficacy, safety, and vision preservation benefits.

Purpose of the Study:

  • To review current understanding of canal opening surgery for glaucoma.
  • To identify knowledge gaps in post-surgical wound healing.
  • To clarify ongoing debates regarding surgical mechanisms and success factors.

Main Methods:

  • Literature review focusing on histopathological studies of canal opening surgery.
  • Analysis of existing research on MIGS outcomes and influencing factors.
  • Synthesis of current scientific opinions and controversies.

Main Results:

  • Histopathological data on post-MIGS wound healing is limited.
  • Mechanisms of intraocular pressure reduction require further elucidation.
  • Discrepancies exist regarding optimal surgical techniques and success predictors.

Conclusions:

  • Further research is essential for a comprehensive understanding of MIGS.
  • Clarifying wound healing and success factors will improve glaucoma treatment.
  • Systematic reviews and meta-analyses are needed to guide clinical practice.