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Updated: Jun 25, 2026

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
Published on: October 14, 2021
Abstract:
Two patients with bipolar disorder had been treated for years with lithium without any complications but began to develop symptoms of rigidity and an altered gait, namely symptoms compatible with a diagnosis of Parkinsonism with an action tremor. In both patients lithium levels were within the therapeutic range. Medication-induced Parkinsonism occurs frequently in patients using antipsychotic medication, but is a rare complication in patients receiving long term treatment with lithium. The lithium dosage was reduced gradually and within a few months all neurological symptoms subsided completely.
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