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Contrast-enhanced MR angiography using time resolved interleaved projection sampling with three-dimensional Cartesian

¹Department of Radiology, University of California, San Diego, California 92103-8756, USA. jiangdu@ucsd.edu

Magnetic Resonance in Medicine

|February 6, 2009

Summary

This study introduces a novel imaging technique, time-resolved projection sampling with 3D Cartesian phase and slice encoding (TRIPPS), for faster contrast-enhanced MR angiography. TRIPPS achieves high temporal resolution while improving robustness against common imaging artifacts.

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Area of Science:

Magnetic Resonance Imaging
Medical Imaging Physics
Cardiovascular Imaging

Background:

Undersampled projection reconstruction (PR) offers high temporal resolution for contrast-enhanced MR angiography (CE-MRA).
However, PR techniques are susceptible to artifacts like eddy currents and gradient errors.
Combining PR's speed with Cartesian imaging's robustness is a key goal in MRA development.

Purpose of the Study:

To introduce and validate a novel imaging technique, time-resolved projection sampling with 3D Cartesian phase and slice encoding (TRIPPS).
To combine the temporal efficiency of PR with the artifact resilience of Cartesian imaging for CE-MRA.
To achieve high temporal resolution CE-MRA suitable for dynamic vascular imaging.

Main Methods:

Developed TRIPPS, partitioning 3D Cartesian k-space into half projections along radial trajectories with Cartesian phase/slice encoding.
Interleaved groups of half projections to uniformly cover k-space.
Employed a view-sharing sliding window algorithm for dynamic image reconstruction.

Main Results:

Demonstrated the feasibility of TRIPPS for CE-MRA in healthy volunteers.
Achieved high temporal resolution of 2 seconds per frame.
Successfully visualized renal, pulmonary, and intracranial vasculatures.

Conclusions:

TRIPPS effectively merges the speed of PR with the robustness of Cartesian imaging for CE-MRA.
The technique provides high temporal resolution, enabling dynamic imaging of vascular structures.
TRIPPS shows promise for advanced applications in cardiovascular and neurovascular imaging.