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Otitis externa malignum.
1Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Journal of Chemotherapy (Florence, Italy)
|June 1, 1991
Summary
Norfloxacin monotherapy effectively treated Pseudomonas otitis externa malignum in elderly diabetic patients. This antibiotic regimen achieved a 100% cure rate with good tolerance, avoiding surgery.
Area of Science:
- Infectious Diseases
- Otolaryngology
- Pharmacology
Background:
- Malignant otitis externa (MOE) is a severe infection, particularly in elderly diabetic patients.
- Pseudomonas aeruginosa is the most common pathogen in MOE.
- Effective and safe treatment options for MOE are crucial.
Purpose of the Study:
- To evaluate the efficacy and safety of norfloxacin monotherapy for Pseudomonas otitis externa malignum.
- To assess the clinical and bacteriological outcomes of norfloxacin treatment.
- To determine the tolerability of norfloxacin in elderly diabetic patients.
Main Methods:
- A study involving twelve elderly diabetic patients with Pseudomonas otitis externa malignum.
- Treatment administered: Norfloxacin 400 mg twice daily (b.i.d.) for 2-5 weeks.
- Outcomes assessed: Clinical cure, bacteriological eradication, and adverse events.
Main Results:
- A 100% bacteriological and clinical cure rate was achieved in all patients.
- Norfloxacin was well-tolerated, with only mild drowsiness reported in two patients.
- No surgical intervention was required for any patient.
Conclusions:
- Norfloxacin monotherapy is a highly effective and safe treatment for Pseudomonas otitis externa malignum in elderly diabetic patients.
- This approach offers a non-surgical alternative with excellent outcomes.
- Further research may support norfloxacin as a first-line treatment option.