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Schizophrenia

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Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.

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Related Experiment Video

Updated: Jun 25, 2026

A Method to Study Adaptation to Left-Right Reversed Audition

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Published on: October 29, 2018

Neural correlates of automatic and controlled auditory processing in schizophrenia.

Rajendra A Morey¹, Teresa V Mitchell, Seniha Inan

¹Duke-UNC Brain Imaging and Analysis Center, Department of Psychiatry, Duke University, Box 3918, Durham, NC 27707, USA. morey@biac.duke.edu

The Journal of Neuropsychiatry and Clinical Neurosciences

|February 7, 2009

Summary

Individuals with schizophrenia show altered brain activity during auditory processing. Functional MRI revealed widespread neural dysfunction in patients, particularly during automatic and controlled attention tasks.

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Area of Science:

Neuroscience
Cognitive Psychology
Psychiatry

Background:

Schizophrenia is characterized by deficits in selective attention and sensory information processing.
Understanding the neural underpinnings of these cognitive impairments is crucial for developing effective treatments.

Purpose of the Study:

To investigate differences in brain function between individuals with schizophrenia and healthy controls during auditory processing.
To examine neural activation patterns during both automatic (unattended) and controlled (attended) auditory information processing.

Main Methods:

Event-related functional magnetic resonance imaging (fMRI) was employed.
Participants included 26 individuals with schizophrenia and 17 healthy comparison subjects.
Brain activity was measured during tasks involving automatic and controlled auditory processing.

Main Results:

The schizophrenia group exhibited reduced neural activation in temporal and prefrontal regions during automatic auditory processing.
Controlled auditory processing in schizophrenia was linked to dysfunction across frontotemporal and subcortical brain areas.
The distinction in brain activation between automatic and controlled processing was less pronounced in patients compared to controls.

Conclusions:

Schizophrenia involves widespread neural dysfunctions affecting both automatic and controlled auditory information processing.
These findings highlight the impact of schizophrenia on fundamental sensory and attentional brain mechanisms.
The results suggest that attentional deficits in schizophrenia may stem from disruptions in frontotemporal and subcortical networks.