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Visual P300 and Risk for Psychosis Onset in Youth at Clinical High Risk.

Holly K Hamilton1, Brian J Roach2, Spero Nicholas2

  • 1Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota; Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota; Department of Psychiatry & Behavioral Sciences, University of California, San Francisco, San Francisco, California.

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PubMed
Summary
This summary is machine-generated.

Visual P300 event-related potential (ERP) deficits are linked to psychosis onset in at-risk individuals. Reduced P3b amplitude predicts earlier conversion, showing potential as a biomarker for psychosis development.

Keywords:
Clinical high risk for psychosis (CHR)ElectroencephalographyEvent-related potentialsP300Risk predictionSchizophrenia

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Biomarkers

Background:

  • Clinical criteria for psychosis onset prediction are insufficient.
  • Biomarkers are needed to improve outcome prediction in individuals at clinical high risk for psychosis (CHR).
  • Visual P300 event-related potential (ERP) amplitude, known to be reduced in schizophrenia, was investigated in CHR individuals.

Purpose of the Study:

  • To examine visual P300 ERP amplitude in CHR individuals.
  • To determine if P300 amplitude is associated with future psychosis onset.
  • To identify potential biomarkers for psychosis development.

Main Methods:

  • Electroencephalography (EEG) was recorded from 538 CHR individuals and 230 healthy comparison (HC) participants using a visual oddball task.
  • P3b (target stimuli) and P3a (novel stimuli) amplitudes were measured.
  • CHR participants were followed for 24 months to compare converters (n=71) to nonconverters (n=218).

Main Results:

  • P300 amplitudes were reduced in CHR individuals compared to HC.
  • Future CHR converters showed greater P3b deficits than nonconverters and HC.
  • Reduced target P3b amplitude predicted earlier psychosis conversion, even after adjusting for symptom severity.

Conclusions:

  • Visual target P3b deficits are associated with psychosis conversion in at-risk individuals.
  • These deficits correlate with the imminence of psychosis conversion.
  • Visual P3b amplitude shows promise as a biomarker for predicting psychosis onset.