Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Nonionizing Millimeter-Wave on Spheroid-like Irradiated Non-Small-Cell Lung Cancer (NSCLC) Cells.

International journal of molecular sciences·2026
Same author

The neuropeptide neuromedin U receptor NMUR-1 buffers insulin receptor signaling in bacteria-dependent C. elegans survival.

PLoS genetics·2026
Same author

Evaluating Sycophancy in Frontier Models Using Persona-Driven Challenge.

medRxiv : the preprint server for health sciences·2026
Same author

Genetically engineered <i>Spirulina plantensis</i> producing human insulin as a potential novel oral drug delivery carrier.

Biomaterials science·2026
Same author

BNB/NBN-Phenalenyl-2'-deoxyuridines as a Fluorophore-Quencher Pair in DNA.

Angewandte Chemie (International ed. in English)·2026
Same author

2'-O-methylation-dependent installation of N<sup>2</sup>-methylguanosine in the U6 internal stem loop facilitates efficient spliceosome assembly.

Nature communications·2026

Related Experiment Video

Updated: Jun 25, 2026

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
09:28

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Published on: January 10, 2017

Multimodal optical sensing and analyte specificity using single-walled carbon nanotubes.

Daniel A Heller, Hong Jin, Brittany M Martinez

    Nature Nanotechnology
    |February 7, 2009
    PubMed
    Summary

    This study introduces a novel nanoscale biosensor using paired single-walled carbon nanotubes for sensitive, label-free detection of genotoxic agents. The sensor uniquely identifies analytes in real-time within live cells, advancing molecular diagnostics.

    More Related Videos

    Fabrication of Carbon Nanotube High-Frequency Nanoelectronic Biosensor for Sensing in High Ionic Strength Solutions
    12:20

    Fabrication of Carbon Nanotube High-Frequency Nanoelectronic Biosensor for Sensing in High Ionic Strength Solutions

    Published on: July 22, 2013

    Localization and Relative Quantification of Carbon Nanotubes in Cells with Multispectral Imaging Flow Cytometry
    14:09

    Localization and Relative Quantification of Carbon Nanotubes in Cells with Multispectral Imaging Flow Cytometry

    Published on: December 12, 2013

    Related Experiment Videos

    Last Updated: Jun 25, 2026

    Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
    09:28

    Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

    Published on: January 10, 2017

    Fabrication of Carbon Nanotube High-Frequency Nanoelectronic Biosensor for Sensing in High Ionic Strength Solutions
    12:20

    Fabrication of Carbon Nanotube High-Frequency Nanoelectronic Biosensor for Sensing in High Ionic Strength Solutions

    Published on: July 22, 2013

    Localization and Relative Quantification of Carbon Nanotubes in Cells with Multispectral Imaging Flow Cytometry
    14:09

    Localization and Relative Quantification of Carbon Nanotubes in Cells with Multispectral Imaging Flow Cytometry

    Published on: December 12, 2013

    Area of Science:

    • Nanotechnology and Nanoscience
    • Biomedical Engineering
    • Chemical Sensing

    Background:

    • Single-molecule detection in constrained environments requires sensitive nanoscale sensing elements.
    • Single-walled carbon nanotubes (SWCNTs) offer photostable near-infrared emission and single-molecule sensitivity for optical sensing.
    • Molecular adsorption on SWCNTs can perturb their electronic structure, enabling optical signal transduction.

    Discussion:

    • A pair of SWCNTs provides at least four modulated optical modes for unique agent fingerprinting.
    • This method differentiates analytes based on alterations in emission band intensity or wavelength.
    • The approach demonstrates label-free optical discrimination between genotoxins.

    Key Insights:

    • Validated in vitro detection of six genotoxic analytes, including chemotherapeutic drugs and reactive oxygen species, spectroscopically classified into four distinct groups.
    • Achieved single-molecule sensitivity in detecting hydrogen peroxide.
    • Successfully detected and identified analytes in real-time within live 3T3 cells.

    Outlook:

    • This work establishes a multiplexed optical detection platform using a nanoscale biosensor.
    • Presents the first label-free tool for optically discriminating between genotoxins in biological systems.
    • Potential for advancing diagnostics and understanding cellular responses to genotoxic agents.