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Related Concept Videos

Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Neuron Structure01:30

Neuron Structure

Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to cellular...
Neuron Structure01:31

Neuron Structure

Overview

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Related Experiment Video

Updated: Jun 25, 2026

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

[Neuropathological perspective on single slide].

Asao Hirano1

  • 1Division of Neuropathology, Montefiore Medical Center, Bronx, New York 10467-2490, USA.

Rinsho Shinkeigaku = Clinical Neurology
|February 10, 2009
PubMed
Summary
This summary is machine-generated.

This review highlights significant neuropathological findings across macroscopic, microscopic, and electron microscopic levels. These insights aid in diagnosing and understanding various nervous system conditions.

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Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
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Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

Related Experiment Videos

Last Updated: Jun 25, 2026

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

Area of Science:

  • Neuropathology
  • Neuroscience
  • Pathology

Context:

  • Over 50 years of neuropathological experience at Montefiore Medical Center.
  • Focus on significant findings from macroscopic, microscopic, and electron microscopic examinations.
  • Educational presentation of diverse neuropathological observations.

Purpose:

  • To illustrate the diagnostic and understanding utility of key neuropathological findings.
  • To provide an educational overview of 11 distinct neuropathological topics.
  • To share insights gained over a long career in neuropathology.

Summary:

  • Presents 11 distinct neuropathological topics including dura mater alterations, leptomeningeal carcinomatosis, infarcts, neurofibrillary tangles, edema spread, myelin sheath changes, synaptic terminal abnormalities, Lewy bodies, and Hirano bodies.
  • Utilizes macroscopic, microscopic, and electron microscopic images to demonstrate findings.
  • Covers conditions from aging and cancer metastasis to neurodegenerative diseases like motor neuron disease.

Impact:

  • Enhances understanding of the nervous system through visual and analytical neuropathological data.
  • Provides valuable diagnostic insights for neuropathologists and clinicians.
  • Contributes to the educational resources available for studying complex neurological conditions.