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Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although vasectomy...
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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
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Published on: September 16, 2021

Hormonal contraception: present and future.

Giuseppe Benagiano1, Carlo Bastianelli, Manuela Farris

  • 1Department of Obstetrics and Gynecology, University "la Sapienza", Rome, Italy. giuseppe.benagiano@uniroma1.it

Drugs of Today (Barcelona, Spain : 1998)
|February 10, 2009
PubMed
Summary
This summary is machine-generated.

Hormonal contraception has evolved beyond the pill to include various delivery methods and formulations. Modern options offer reduced estrogen doses and new progestins for effective pregnancy prevention and emergency contraception.

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Area of Science:

  • Reproductive endocrinology and pharmacology.
  • Development of pharmaceutical agents for birth control.

Background:

  • Hormonal contraception, initially the oral "Pill", has diversified into multiple administration routes including oral, injectable, transdermal, and intrauterine systems.
  • Current hormonal contraceptives use either combined estrogen and progestin or progestin-only formulations.
  • Significant advancements include reduced ethinylestradiol dosages and the development of novel progestins across four generations.

Purpose of the Study:

  • To review the evolution and current landscape of hormonal contraceptive methods.
  • To highlight pharmacological aspects, including estrogen and progestin components and their dosages.
  • To discuss recent innovations and future directions in contraceptive technology.

Main Methods:

  • Review of existing literature on hormonal contraception.
  • Analysis of pharmacological components and delivery systems.
  • Categorization of progestins by chemical family and generation.

Main Results:

  • Combined hormonal contraceptives now contain significantly lower doses of ethinylestradiol (down to 15 microg).
  • Newer progestins like drospirenone, dienogest, and chlormadinone are incorporated into oral contraceptives.
  • Non-oral and long-acting formulations, including patches, vaginal rings, and intrauterine systems, offer extended contraceptive protection (up to 5 years or more).

Conclusions:

  • Hormonal contraception has seen substantial innovation in formulations, delivery systems, and reduced dosages.
  • Current and emerging methods provide diverse options for effective pregnancy prevention and emergency contraception.
  • Continued research focuses on improving efficacy, safety, and user convenience in contraceptive technologies.