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Updated: Jun 25, 2026
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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
Published on: January 29, 2016
Effects of resistance training in multiple sclerosis
F de Souza-Teixeira1, S Costilla, C Ayán
1Biomedical Science Institute, Facultad de Ciencias de la Actividad Física y del Deporte, University of León, León, Spain. fsout@unileon.es
International Journal of Sports Medicine
|February 10, 2009
Summary
Progressive resistance training significantly improved strength, muscle mass, and functionality in multiple sclerosis patients. This exercise intervention offers a promising, safe therapy to combat functional decline in MS.
Area of Science:
- Neurology
- Exercise Physiology
- Rehabilitation Science
Background:
- Multiple sclerosis (MS) is a chronic neurological disease leading to progressive functional deterioration.
- Maintaining muscle mass and strength is crucial for mobility and quality of life in MS patients.
- Current therapeutic strategies often focus on managing symptoms rather than enhancing physical function.
Purpose of the Study:
- To investigate the effects of an 8-week progressive resistance training program on strength, muscle mass, and functionality in individuals with mild to moderate multiple sclerosis.
- To assess the safety and efficacy of resistance training as a therapeutic intervention for multiple sclerosis.
Main Methods:
- A cohort of 13 multiple sclerosis patients (mean age 43) underwent an 8-week progressive resistance training program (twice weekly, 40-70% maximal voluntary contraction) following an 8-week control period.
- Outcome measures included magnetic resonance imaging of thigh muscles, maximal voluntary contraction, muscular endurance, power, and the Up and Go test for functionality.
Main Results:
- No significant changes were observed during the 8-week control period.
- Following resistance training, significant improvements were noted in isometric strength (+16%), muscular endurance (+84%), maximal power (+51%), and functionality (p<0.001).
- Significant muscular hypertrophy was observed in both thighs (p<0.05).
Conclusions:
- Moderate-intensity progressive resistance training is safe and effective for improving muscle function and mass in multiple sclerosis patients.
- This training modality shows potential as a therapeutic approach to mitigate functional decline associated with multiple sclerosis.
- Resistance exercise can be a valuable addition to the management of multiple sclerosis, enhancing physical capabilities and potentially delaying disability progression.
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