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A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation
Published on: April 27, 2019
Plasma adiponectin in heart transplant recipients
Pierre Ambrosi1, Christiane Oddoze, Alain Nicolay
1Department of Cardiology, Hôpital de la Timone, Marseille, France. pierre.ambrosi@ap-hm.fr
Clinical Transplantation
|February 10, 2009
Summary
In heart transplant recipients, metabolic syndrome is common, but plasma adiponectin levels are usually normal or high, likely due to renal failure, suggesting adiponectin isn't a key factor in their insulin resistance.
Area of Science:
- Cardiology
- Endocrinology
- Nephrology
Background:
- Heart transplant recipients frequently develop metabolic syndrome.
- Renal failure is common post-heart transplantation and may affect adiponectin levels.
- The relationship between adiponectin and metabolic syndrome might be altered in this population.
Purpose of the Study:
- To investigate the association between metabolic syndrome and plasma adiponectin levels in heart transplant recipients.
- To explore the influence of renal function on adiponectin levels in this cohort.
Main Methods:
- A cross-sectional study included 95 heart transplant recipients (mean 8.3 years post-transplant).
- Data collected included physical examination, echocardiography/coronary angiography, and laboratory measurements.
- Creatinine clearance was assessed to evaluate renal function.
Main Results:
- Metabolic syndrome was present in 31% of patients.
- Plasma adiponectin was significantly lower in patients with metabolic syndrome compared to those without (12.5 vs. 16.7 microg/mL, p=0.03).
- Adiponectin levels were generally normal or high; low creatinine clearance correlated with higher adiponectin (R=-0.26, p=0.01).
Conclusions:
- Despite a high prevalence of metabolic syndrome, adiponectin levels were typically normal to high, likely influenced by renal failure.
- Adiponectin may not be a primary driver of insulin resistance in heart transplant recipients.
- Renal function significantly impacts adiponectin levels in this patient group.
