Related Experiment Video
Updated: Jun 25, 2026
08:34
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
Accelerated partial breast irradiation: where do we stand?
1Stanford Cancer Center and Department of Surgery, Section of Surgical Oncology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA. dirbas@stanford.edu
Journal of the National Comprehensive Cancer Network : JNCCN
|February 10, 2009
Summary
Accelerated partial breast irradiation (APBI) offers a shorter radiotherapy course post-lumpectomy. Recent studies show APBI provides local control comparable to whole breast radiotherapy, improving breast conservation options.
Area of Science:
- Oncology
- Radiotherapy
- Breast Cancer Treatment
Background:
- Accelerated partial breast irradiation (APBI) is a shorter radiotherapy regimen for post-lumpectomy breast cancer patients.
- Initial trials indicated high local recurrence rates, prompting further investigation.
Purpose of the Study:
- To evaluate the efficacy and safety of APBI as an alternative to whole breast radiotherapy.
- To assess the impact of patient selection and surgical techniques on APBI outcomes.
Main Methods:
- Review of single and multi-institutional studies, including phase I/II and phase III trials.
- Analysis of local control rates achieved with APBI using four different accelerated radiotherapy methods.
Main Results:
- More recent studies demonstrate local control rates with APBI that are comparable to traditional whole breast radiotherapy.
- Phase I/II studies have provided substantial data on APBI, with ongoing phase III trials.
Conclusions:
- APBI shows promise as a safe and effective option for breast conservation.
- Further phase III studies are crucial to confirm APBI's role in replacing whole breast radiotherapy.
