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Published on: October 18, 2024
Results with early follicular phase recombinant luteinizing hormone supplementation during stimulation for in vitro
Peter Kovacs1, Timea Kovats, Steven G Kaali
1Kaali Institute, IVF Center, 54 Istenhegyi ut, 1125 Budapest, Hungary. peterkovacs1970@hotmail.com
Objective:
To study the effect of early follicular phase recombinant LH supplementation on stimulation outcome among women undergoing IVF using the GnRHa long protocol and recombinant FSH.
Design:
Randomized, controlled trial.
Setting:
Private IVF unit.
Patient(S):
Women under the age of 40 with normal ovarian function undergoing their first or second IVF cycle.
Intervention(S):
All stimulations followed the standard luteal long GnRHa down-regulation protocol. At suppression, patients in the experimental group received 75 IU of rLH daily for 4 days, and recombinant FSH at a fixed starting dose of 150 IU for the first 5 days was started a day later, on day 2 of rLH. In the control group, patients started rFSH at a fixed dose of 150 IU for the first 5 days at suppression.
Main Outcome Measure(S):
Baseline, stimulation, embryology parameters, and treatment outcome were compared. Of primary interest, recombinant FSH need during stimulation was assessed.
Result(S):
Stimulation, embryology parameters, and treatment outcome were comparable. The amount of gonadotropins used and medication expense were similar in the two groups.
Conclusion(S):
Early follicular phase recombinant LH supplementation at a daily dose of 75 IU does not improve response to stimulation among normal responder women undergoing IVF.
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