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Related Concept Videos

Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

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Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)
10:02

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Published on: March 12, 2020

CREM mutations and ADHD symptoms.

Tuuli A Lahti1, Timo Partonen

  • 1National Public Health Institute, Department of Mental Health and Alcohol Research, Mannerheimintie 166, FI-00300 Helsinki, Finland.

Medical Hypotheses
|February 10, 2009
PubMed
Summary
This summary is machine-generated.

Mutations in the CREM gene may explain some attention deficit hyperactivity disorder (ADHD) symptoms, as CREM mutant mice exhibit ADHD-like behaviors. Elevated nocturnal melatonin levels were observed in ADHD patients before treatment.

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Using Brain Activation (nir-HEG/Q-EEG) and Execution Measures (CPTs) in a ADHD Assessment Protocol

Published on: April 1, 2018

Area of Science:

  • Neuroscience
  • Genetics
  • Pharmacology

Background:

  • Attention deficit hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder.
  • CREM (cAMP response element modulator) gene and its protein product play roles in various physiological processes.
  • Previous research suggests potential links between genetic factors and ADHD pathophysiology.

Purpose of the Study:

  • To investigate the potential role of CREM gene mutations or protein abnormalities in ADHD.
  • To explore the behavioral similarities between CREM mutant mice and individuals with ADHD.
  • To examine melatonin levels in ADHD patients in relation to potential CREM involvement.

Main Methods:

  • Behavioral analysis of CREM mutant mice to assess activity, emotional, and stress responses.
  • Urine sample analysis to measure nocturnal melatonin levels in human participants with ADHD before and after methylphenidate treatment.
  • Genetic analysis to investigate CREM gene status in ADHD patients (implied).

Main Results:

  • CREM mutant mice displayed behaviors analogous to ADHD symptoms, including hyperactivity and altered emotional/stress responses.
  • All four ADHD participants exhibited elevated nocturnal melatonin levels prior to methylphenidate treatment.
  • These findings suggest a potential link between CREM function and ADHD symptomatology.

Conclusions:

  • Abnormalities in CREM protein function or CREM gene mutations may underlie certain ADHD symptoms.
  • Nocturnal melatonin levels could serve as a potential biomarker in some ADHD cases.
  • Further research is warranted to elucidate the precise mechanisms connecting CREM, melatonin, and ADHD.