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The pathological role of transient receptor potential channels in heart disease

Hiroyuki Watanabe1, Manabu Murakami, Takayoshi Ohba

  • 1Second Department of Internal Medicine, Akita University School of Medicine, Akita, Japan.

Circulation Journal : Official Journal of the Japanese Circulation Society
|February 10, 2009
PubMed

Insights

Transient receptor potential (TRP) channels are crucial cellular sensors in the heart. This review details their pathological roles in heart disease, suggesting TRP channels as potential therapeutic targets.

Area of Science:

  • Cardiovascular Physiology
  • Molecular Biology
  • Medical Science

Background:

  • Transient receptor potential (TRP) channels are ubiquitous in human tissues, including the heart and vasculature.
  • These Ca(2+)-permeable channels function as multifunctional cellular sensors, regulating vital processes like contraction, proliferation, and cell death.
  • Their fundamental roles underscore the urgency of investigating TRP channel involvement in human diseases.

Purpose of the Study:

  • To review current knowledge on the pathological role of TRP channels in heart disease.
  • To highlight specific TRP channels implicated in various cardiac conditions.
  • To explore the potential of TRP channels as novel therapeutic targets for heart disease.

Main Methods:

  • Literature review of existing research on TRP channels and cardiovascular disease.
  • Synthesis of evidence linking specific TRP channel subtypes to cardiac pathologies.
  • Identification of TRP channels with potential roles in disease pathogenesis.

Main Results:

  • Upregulation of TRPC channels is associated with cardiac hypertrophy and heart failure.
  • TRPC1, TRPC6, and TRPV2 are implicated in muscular dystrophy-related cardiomyopathy.
  • TRPC6 or TRPM4 contribute to delayed after-depolarizations, while TRPP2 is vital for septal development.
  • Neuronal TRPV1 acts as a pain-sensing channel.

Conclusions:

  • TRP channels play significant, multifaceted roles in cardiovascular health and disease.
  • Specific TRP channel dysfunctions are linked to conditions like hypertrophy, heart failure, and cardiomyopathy.
  • TRP channels represent promising targets for future pharmacological interventions in treating heart disease.

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