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Updated: Jun 25, 2026

Measuring Endoplasmic Reticulum Stress and Unfolded Protein Response in HIV-1 Infected T-Cells and Analyzing its Role in HIV-1 Replication
Published on: June 14, 2024
The stress-inducible HspB8-Bag3 complex induces the eIF2alpha kinase pathway: implications for protein quality
1Department of Radiation and Stress Cell Biology, University Medical Center Groningen, A. Deusinglaan 1, Groningen, The Netherlands. s.carra@med.umcg.nl
Abstract:
The recently discovered HspB8-Bag3 complex participates in protein quality control through a mechanism that requires the activation of the eIF2alpha signaling pathway and that leads to protein synthesis inhibition and autophagy stimulation. Both processes help to protect the cells against the accumulation of aggregate-prone proteins, which may be relevant in many protein-conformational neurodegenerative disorders. Besides, this activity of HspB8-Bag3 may have important implications during viral infection.
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