Related Experiment Videos
Correlations between left ventricular mass and systolic blood pressure at rest and during maximal exercise in
K M Knutsen1, S Michelsen, J E Otterstad
1Medical Department, Vestfold Central Hospital, Tønsberg, Norway.
Insights
In men with moderate hypertension, resting systolic blood pressure (SBP) is as effective as exercise SBP in predicting left ventricular mass index (LVMI). This finding is crucial for understanding cardiac remodeling in hypertensive individuals.
Area of Science:
- Cardiology
- Hypertension Research
Background:
- Left ventricular mass index (LVMI) is a key indicator of cardiac remodeling in hypertension.
- Understanding predictors of LVMI is essential for managing cardiovascular risk.
Purpose of the Study:
- To investigate the relationship between resting and exercise systolic blood pressure (SBP) and LVMI in men with moderate hypertension.
Main Methods:
- Eighty-seven men with moderate hypertension underwent echocardiography and maximal ergometer bicycle testing.
- Left ventricular mass index (LVMI) was calculated using the Penn convention.
- Linear and multiple regression analyses were performed to assess correlations.
Main Results:
- A significant correlation was found between LVMI and both resting SBP (r=0.48) and exercise SBP (r=0.39).
- Multiple regression analysis, controlling for age, work, and cholesterol, confirmed significant correlations for both resting (t=4.07) and exercise SBP (t=3.25).
- Exercise SBP did not demonstrate superior predictability for LVMI compared to resting SBP.
Conclusions:
- In patients with established moderate hypertension, resting systolic blood pressure is a significant predictor of left ventricular mass index.
- Exercise systolic blood pressure offers no additional predictive value for LVMI over resting blood pressure in this population.
Abstract:
We examined 87 men with moderate hypertension (diastolic blood pressure, DPB, greater than or equal to 95 and less than 110 mmHg) (mean age 45, range 22-64, years) with echocardiography and maximal ergometer bicycle test. Left ventricular mass index (LVMI) was calculated according to the Penn convention. Mean LVMI was 126 (60-210) g/m2. The maximal systolic blood pressure (SBP) during exercise was on average 217 (155-260) mmHg. Linear regression analysis revealed a significant correlation between LVMI and SBP at rest (r = 0.48, P less than 0.001) and during exercise (r = 0.39, P less than 0.001). Multiple regression analysis correcting for differences in age, cumulative work and cholesterol level revealed a significant correlation between LVMI and SBP at rest (t = 4.07, P less than 0.0001) and during exercise (t = 3.25, P = 0.002). Thus in patients with established, moderate hypertension exercise SBP is not more predictable for LVMI than is SBP at rest.