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Updated: Jun 25, 2026
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
Comparison of methods to measure heart size using noncontrast-enhanced computed tomography: correlation with left
Kurt R Daniel1, Alain G Bertoni, Jingzhong Ding
1Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. krdaniel@wfubmc.edu
Objective:
Left ventricular (LV) mass is a useful independent predictor of cardiovascular events. We sought to develop a new correlate of LV mass using noncontrast-enhanced cardiac computed tomography (NCE-CCT).
Methods:
We assessed 22 different ventricular measurements made with NCE-CCT in 60 participants in the Multi-Ethnic Study of Atherosclerosis. The primary outcome was the correlation between the NCE-CCT measurements and magnetic resonance imaging (MRI)-derived LV mass.
Results:
Correlation coefficients (r) for the 22 NCE-CCT techniques in comparison to MRI-derived LV mass ranged from 0.12 to 0.80, with 14 of the 22 techniques having r > 0.7. The highest correlation was achieved using the modified Simpson Rule method to determine the biventricular volume (r = 0.80; P < 0.001). Interrater reliability was good, with intraclass correlation coefficients of 0.84 to 0.90 for the best (r > 0.75) NCE-CCT methods.
Conclusions:
Noncontrast-enhanced cardiac computed tomography measurements of both biventricular volume and LV volume correlated well with MRI-derived LV mass in a population free of clinical cardiovascular disease.
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