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Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...

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Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
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Testosterone replacement therapy following radical prostatectomy.

Mohit Khera1, Ethan D Grober2, Bobby Najari3

  • 1Department of Urology, Baylor College of Medicine, Houston, TX, USA;.

The Journal of Sexual Medicine
|February 12, 2009
PubMed
Summary
This summary is machine-generated.

Testosterone replacement therapy (TRT) safely improves testosterone levels in hypogonadal men after radical prostatectomy (RP). This study found no increase in prostate-specific antigen (PSA) values, indicating no tumor recurrence risk from TRT.

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Area of Science:

  • Urology
  • Andrology
  • Oncology

Background:

  • Clinicians hesitate to prescribe testosterone replacement therapy (TRT) post-radical prostatectomy (RP) due to concerns about prostate cancer recurrence.
  • Emerging evidence suggests TRT may be safe and beneficial in select patients after RP.

Purpose of the Study:

  • To evaluate changes in prostate-specific antigen (PSA) and testosterone levels in hypogonadal men treated with TRT after RP.
  • To assess the influence of pathologic Gleason grade on PSA levels post-TRT.

Main Methods:

  • Retrospective review of hypogonadal men who received TRT after RP.
  • Analysis of PSA and testosterone levels before and after TRT.
  • Inclusion criteria: undetectable PSA and negative surgical margins post-RP.

Main Results:

  • Fifty-seven men initiated TRT post-RP, with a mean follow-up of 13 months.
  • Mean testosterone levels significantly increased from 255 to 459 ng/dL (P < 0.001).
  • No significant increase in PSA values was observed, with no biochemical recurrence.

Conclusions:

  • TRT effectively restores testosterone levels in hypogonadal men post-RP.
  • TRT does not appear to increase PSA values or risk of recurrence in carefully selected patients.
  • TRT is a viable option for managing hypogonadism after RP.