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Intravascular Delivery of Biologics to the Rat Kidney
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Published on: September 1, 2016

Cutaneous complications among i.v. buprenorphine users.

Roger C M Ho1, Emily C L Ho, Anselm Mak

  • 1Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. pcmrhcm@nus.edu.sg

The Journal of Dermatology
|February 12, 2009
PubMed
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Intravenous buprenorphine hydrochloride misuse frequently causes skin infections like cellulitis and abscesses. Higher respiratory rates on admission predict longer hospital stays for these patients.

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Pharmacology

Background:

  • Intravenous (IV) buprenorphine hydrochloride misuse is linked to significant medical issues.
  • Cutaneous manifestations, particularly soft tissue infections, are common consequences.

Observation:

  • A study of 130 IV buprenorphine abusers found a 31% prevalence of cutaneous complications.
  • Cellulitis and skin abscesses were the most frequent issues, with Methicillin-sensitive Staphylococcus aureus being the commonest isolate.

Findings:

  • Admission respiratory rate was a significant predictor of longer hospitalization duration.
  • Antibiotics like cloxacillin and penicillin were commonly used, with 24% requiring surgical intervention.

Implications:

  • Cutaneous complications are prevalent in IV buprenorphine users.
  • Monitoring respiratory rates on admission can help predict hospital stay length.
  • Appropriate antibiotic selection based on local surveillance is crucial for managing these infections and reducing hospitalization.