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Updated: Jun 25, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
Allergic contact dermatitis from temporary henna tattoo
Dragan L Jovanovic1, Maja R Slavkovic-Jovanovic
1Department of Dermatovenereology, Medical Faculty Nis, Clinic of Dermatology and Venereology, Nis, Serbia. bukid@eunet.rs
Temporary henna tattoos can cause allergic reactions. Para-phenylenediamine (PPD) in black henna triggers allergic contact dermatitis, as seen in a child treated successfully with medication.
Area of Science:
- Dermatology
- Allergology
- Toxicology
Background:
- Temporary henna tattooing is a popular cosmetic practice.
- Henna dye, derived from Lawsonia inermis, is often mixed with para-phenylenediamine (PPD) to achieve a black color and faster dyeing.
- Para-phenylenediamine (PPD) is a known potent contact sensitizer.
Observation:
- A case study involving a 9-year-old boy who developed allergic contact dermatitis.
- The allergic reaction was linked to a temporary henna tattoo.
- Patch testing confirmed a positive reaction specifically to PPD.
Findings:
- The patient presented with symptoms of allergic contact dermatitis.
- Diagnosis was confirmed via patch testing, identifying PPD as the allergen.
- Treatment involved topical corticosteroids and oral antihistamines.
Implications:
- Highlights the potential risks associated with PPD in temporary henna tattoos.
- Underscores the importance of accurate allergen identification in pediatric dermatology.
- Suggests that while effective treatments exist, residual hypopigmentation may occur.
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