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Updated: Jun 23, 2026
08:16
Comparative Lesions Analysis Through a Targeted Sequencing Approach
Published on: November 5, 2019
Acrokeratosis paraneoplastica (Bazex syndrome)
Milanka S Ljubenovic1, Dragisa B Ljubenovic, Ivana I Binic
1Clinical center Nis, Department of Dermatology and Venerology, Nis, Serbia. milanka_ljubenovic@yahoo.com
Summary
Bazex syndrome, a rare skin condition, presents as scaly plaques and may indicate underlying cancer. Early recognition by dermatologists is crucial for timely diagnosis of internal malignancies.
Area of Science:
- Dermatology
- Oncology
Background:
- Acrokeratosis paraneoplastica of Bazex is a rare paraneoplastic syndrome.
- It is characterized by scaly, hyperkeratotic, psoriasiform plaques on acral surfaces.
Observation:
- A 56-year-old male presented with hyperkeratotic plaques on palms, soles, ear lobes, and nose.
- A tumorous swelling was found on the left side of his neck.
- Histopathology revealed a solid anaplastic metastatic tumor.
Findings:
- Bazex syndrome is a marker for neoplastic conditions, predominantly squamous cell carcinoma of the upper aerodigestive tract.
- The syndrome can manifest before the diagnosis of internal malignancies.
Implications:
- Early recognition of Bazex syndrome by dermatologists is vital for the prompt diagnosis of associated malignant processes.
- This highlights the importance of a multidisciplinary approach in managing patients with paraneoplastic syndromes.
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