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Psoriasis associated with ulcerative colitis and Crohn's disease
A D Cohen1, J Dreiher, S Birkenfeld
1Clalit Health Services, Tel Aviv, Hod Hasharon, Israel. arcohen@clalit.org.il
Journal of the European Academy of Dermatology and Venereology : JEADV
|February 12, 2009
Summary
Psoriasis is linked to inflammatory bowel diseases, including Crohn's disease and ulcerative colitis. This study confirms a significant association between psoriasis and both conditions, highlighting the need for further research into ulcerative colitis comorbidities.
Area of Science:
- Dermatology and Gastroenterology
- Immunodermatology and Inflammatory Bowel Diseases
Background:
- Psoriasis and Crohn's disease share known epidemiological, pathogenic, and genetic links.
- The association between psoriasis and ulcerative colitis is less frequently reported.
Purpose of the Study:
- To investigate the association between psoriasis and inflammatory bowel disease (IBD).
- To compare the prevalence of IBD in psoriasis patients versus controls.
Main Methods:
- A case-control study utilizing a large medical dataset from Clalit Health Services.
- Logistic multivariate models were used to compare IBD prevalence in 12,502 psoriasis patients and 24,287 matched controls.
Main Results:
- Psoriasis patients showed a significantly higher prevalence of both Crohn's disease and ulcerative colitis compared to controls.
- Psoriasis was independently associated with Crohn's disease (OR, 2.49) and ulcerative colitis (OR, 1.64).
- The observed association was independent of anti-tumour necrosis factor-alpha therapy.
Conclusions:
- Psoriasis is significantly associated with both Crohn's disease and ulcerative colitis.
- Future research on psoriasis comorbidities should prioritize ulcerative colitis.
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