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Related Experiment Video

Updated: Jun 25, 2026

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
14:23

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

Published on: August 31, 2014

HBV genotypes in India: do they influence disease severity?

Kaushal Madan1, Yogesh Batra, Vishnubhatla Sreenivas

  • 1Department of Gastroenterology, All india Institute of Medical Sciences, New Delhi, India.

Hepatology Research : the Official Journal of the Japan Society of Hepatology
|February 12, 2009
PubMed
Summary

Hepatitis B virus (HBV) genotypes A and D do not significantly impact liver disease severity or treatment outcomes in Indian patients. This study found similar clinical and histological outcomes across different HBV genotypes.

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A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
14:23

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

Published on: August 31, 2014

Area of Science:

  • Hepatology
  • Virology
  • Genetics

Background:

  • The association between Hepatitis B virus (HBV) genotypes, particularly A and D, and the severity of liver disease remains a subject of debate.
  • Understanding these associations is crucial for predicting disease progression and tailoring treatment strategies.

Purpose of the Study:

  • To investigate the influence of different HBV genotypes on the severity of liver disease in a cohort of Indian patients.
  • To compare clinical, histological, and biochemical markers of disease severity across various HBV genotypes.

Main Methods:

  • Genotyping of HBV in 247 infected patients using enzyme-linked immunosorbent assay (ELISA) and restriction fragment length polymorphism (RFLP).
  • Analysis included patients with acute hepatitis, carriers, chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC).
  • Comparison of genotype distribution and disease severity markers, including liver biopsy data (histological activity index and fibrosis stage).

Main Results:

  • Hepatitis B virus genotype D was most prevalent (68.3%), followed by genotype A (25.7%) and genotype C (5.9%).
  • No significant differences in genotype distribution were observed across different stages of liver disease, from acute hepatitis to hepatocellular carcinoma.
  • Liver biopsy results, including histological activity index and fibrosis stage, were similar among patients infected with HBV genotypes A, C, and D.

Conclusions:

  • Hepatitis B virus genotypes A and D do not appear to influence the clinical or histological severity of liver disease in the Indian population.
  • Therapeutic responses to treatment were also found to be similar across the studied HBV genotypes.