All or none hypothesis: a global-default mode that characterizes the brain and mind
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Updated: Jun 25, 2026

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
Published on: December 28, 2010
1Department of Psychiatry, University of British Columbia, Canada. adele.diamond@ubc.ca
Abstract:
It is proposed that the mind and brain often work at a gross level and only with fine tuning or inhibition act in a more differentiated manner, even when one might think the domains being issued the global command should be distinct. This applies to disparate findings in cognitive science and neuroscience in both children and adults. Thus, it is easier to switch everything, or nothing, than to switch one thing (the rule one is following or which button to press) but not the other. It is easier to issue the same command to both hands than to move only one hand. If one needs to respond to the opposite (or antonym) of a stimulus, one is faster if the correct response is to the side opposite the stimulus. People tend to think of the nervous system as sending out very precise commands only to the relevant recipient, but it appears that often the command goes out more globally and then parts of the system need to be inhibited from acting on the command.
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