Family-based association analysis of S100A8 genetic polymorphisms with aggressive periodontitis
1Department of Periodontology, School and Hospital of Stomatology, Peking University, 22 Zhong Guan Cun Nan Da Jie, Beijing, China.
Journal of Periodontal Research
|February 13, 2009
Summary
This study found that the S100A8 gene polymorphism rs3795391 is associated with aggressive periodontitis (AgP) susceptibility in Chinese families. Allele A showed preferential transmission to affected individuals, supporting its role in AgP.
Area of Science:
- Genetics
- Periodontology
- Molecular Biology
Background:
- S100A8 protein is linked to inflammatory diseases like periodontitis.
- Previous studies suggested a link between S100A8 gene polymorphisms (rs3795391 and rs3806232) and aggressive periodontitis (AgP) in Chinese populations.
- Family-based studies are needed to confirm these associations.
Purpose of the Study:
- To investigate the association between S100A8 gene polymorphisms (rs3795391 and rs3806232) and AgP within nuclear families.
- To validate previous population-based findings using a family-based approach.
Main Methods:
- Recruited 204 subjects from 73 nuclear families.
- Diagnosed participants for periodontitis based on the 1999 classification.
- Analyzed SNPs rs3795391 and rs3806232 using PCR-RFLP and Family-Based Association Test (FBAT) software.
Main Results:
- A significant association was found between SNP rs3795391 and AgP in an additive genetic model (p=0.0459).
- Allele A of rs3795391 demonstrated preferential transmission to AgP-affected individuals (p=0.0459).
- SNP rs3806232 showed no significant association with AgP in any tested model.
Conclusions:
- The findings support the hypothesis that the S100A8 gene polymorphism rs3795391 contributes to AgP susceptibility.
- This is the first study to utilize FBAT for genetic analysis of AgP in this context.
- The S100A8 gene is a potential genetic factor in the development of aggressive periodontitis.
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