Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pharyngitis01:23

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic sinusitis...
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sphenoid sinus pneumatization types, extensions and adjacent neurovascular structures: a systematic review with meta-analysis and meta-regression.

Anatomical science international·2026
Same author

Diving surgery for ACTH secreting pituitary adenomas: a retrospective single center cohort study.

British journal of neurosurgery·2026
Same author

Remission in Global Airway Diseases: EUFOREA Consensus Paper.

Allergy·2026
Same author

Indication for biologic treatment in a real-world cohort of chronic rhinosinusitis patients according to international recommendations: Evidence from the European CRS outcome registry (CHRINOSOR).

The World Allergy Organization journal·2026
Same author

Morphological Variability of Sphenoid Sinus Pneumatization and Its Impact on Adjacent Neurovascular Structures.

Diagnostics (Basel, Switzerland)·2026
Same author

Hearing loss and cochlear implantation in Chudley McCullough syndrome: A case series.

Cochlear implants international·2026

Related Experiment Video

Updated: Jun 25, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

The mold conundrum in chronic hyperplastic sinusitis.

Fenna A Ebbens1, Christos Georgalas, Wytske J Fokkens

  • 1Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands. f.a.ebbens@amc.uva.nl

Current Allergy and Asthma Reports
|February 13, 2009
PubMed
Summary
This summary is machine-generated.

The role of fungi in chronic rhinosinusitis (CRS) is unclear, as fungi are found in both patients and healthy individuals. Current evidence does not definitively prove fungal involvement in CRS pathogenesis or the effectiveness of antifungal treatments.

More Related Videos

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections
06:57

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections

Published on: May 8, 2017

Related Experiment Videos

Last Updated: Jun 25, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections
06:57

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections

Published on: May 8, 2017

Area of Science:

  • Otolaryngology
  • Mycology
  • Immunology

Background:

  • Fungi are frequently detected in the nasal passages and paranasal sinuses of individuals with chronic rhinosinusitis (CRS).
  • The presence of fungi is not exclusive to CRS patients, as they are also found in healthy individuals.
  • Existing theories propose mechanisms for fungal impact on sinus mucosa in susceptible individuals.

Purpose of the Study:

  • To investigate the unclear role of fungi in the pathogenesis of chronic rhinosinusitis.
  • To identify potentially pathogenic fungal species implicated in CRS.
  • To characterize the specific immunologic responses to fungi that may contribute to CRS development.

Main Methods:

  • Detection of fungal presence in nasal and sinus cavities of CRS patients and healthy controls.
  • Review of existing theories on fungal mechanisms affecting sinus mucosa.
  • Evaluation of immunologic data and clinical outcomes following antifungal therapy.

Main Results:

  • Fungi are ubiquitously detected in both CRS patients and healthy controls.
  • Convincing immunologic data linking fungi to CRS pathogenesis is currently lacking.
  • Clinical evidence supporting improvement in CRS after antifungal therapy is not established.

Conclusions:

  • The pathogenic role of fungi in chronic rhinosinusitis remains unproven.
  • Further research is required to elucidate fungal involvement and host immune responses in CRS.
  • Antifungal therapy efficacy in CRS is not supported by current evidence.