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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...

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Related Experiment Video

Updated: Jun 25, 2026

Gene Expression Profiling of Infecting Microbes Using a Digital Bar-coding Platform
09:13

Gene Expression Profiling of Infecting Microbes Using a Digital Bar-coding Platform

Published on: January 13, 2016

Expression Profiling Using Affymetrix GeneChip Microarrays.

Herbert Auer1, David L Newsom, Karl Kornacker

  • 1Columbus Children's Research Institute, Columbus, OH, USA.

Methods in Molecular Biology (Clifton, N.J.)
|February 13, 2009
PubMed
Summary
This summary is machine-generated.

Gene expression profiling using microarrays, particularly Affymetrix GeneChips, offers a comprehensive view of cellular activity. This technology aids in understanding diseases and developing personalized medical treatments.

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Last Updated: Jun 25, 2026

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DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning
09:27

DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning

Published on: March 15, 2011

Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Mammalian genomes contain approximately 25,000 genes.
  • Gene expression levels vary and provide insights into cellular function.
  • Genome-wide expression profiling is crucial for biological and medical research.

Purpose of the Study:

  • To highlight the significance of gene expression profiling in understanding biological systems.
  • To emphasize the role of microarrays, specifically Affymetrix GeneChips, in this field.
  • To discuss the potential applications of expression profiling in medical research.

Main Methods:

  • Utilizing microarrays for genome-wide expression profiling.
  • Employing Affymetrix GeneChips as a primary technology.
  • Analyzing gene expression data from thousands of genes simultaneously.

Main Results:

  • Microarrays provide a comprehensive picture of steady-state transcript levels.
  • Affymetrix GeneChips are widely adopted, evidenced by over 3,000 publications.
  • Expression profiling data can reveal disease mechanisms and therapeutic targets.

Conclusions:

  • Microarray-based gene expression profiling is a powerful tool in basic and applied research.
  • This technology holds significant promise for advancing medical research, including disease understanding and personalized medicine.
  • Affymetrix GeneChips are a leading platform for robust and reproducible expression profiling.