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Updated: Jun 25, 2026
08:42
Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
Published on: May 19, 2015
[Gender differences in the neurocognitive components of depression]
Andrea Sárosi1, Xénia Gonda, Gabriella Balogh
1Semmelweis Egyetem, Kútvölgyi Klinikai Tömb, Klinikai és Kutatási Mentálhigiénés Osztály.
Summary
Major depression is linked to neurocognitive deficits. This study found depressed women showed greater impairments in visual recall and cognitive interference compared to depressed men.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Psychology
Context:
- Major depressive disorder (MDD) is associated with significant neurocognitive deficits.
- Understanding gender-specific differences in these deficits is crucial for targeted interventions.
Purpose:
- To investigate gender differences in neurocognitive impairment among patients with major depressive disorder.
- To compare the performance of depressed women and men on various cognitive tests.
Summary:
- 96 patients with MDD were assessed using standardized depression scales and a battery of neurocognitive tests.
- Depressed patients performed worse than controls across all cognitive domains.
- Depressed women exhibited significantly poorer performance than depressed men on tests of visual recall and cognitive interference.
Impact:
- Findings highlight gender-specific patterns of neurocognitive impairment in MDD.
- Suggests potential role of hippocampal lateralization in observed gender differences.
- Informs the development of gender-tailored therapeutic strategies for depression.
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