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Related Concept Videos

Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

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Updated: Jun 25, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

Incomplete Kawaski disease: are we missing it?

Abdul Gaffar Billoo1, Saira Waqar Lone, Salman Siddiqui

  • 1Department of Pediatrics, The Aga Khan University Hospital, Karachi.

JPMA. the Journal of the Pakistan Medical Association
|February 14, 2009
PubMed
Summary
This summary is machine-generated.

This case report highlights incomplete Kawasaki disease (KD) in a child presenting with fever and specific symptoms. Early diagnosis and treatment with immunoglobulin and aspirin led to improvement, preventing severe coronary artery complications.

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Last Updated: Jun 25, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

Area of Science:

  • Pediatric Rheumatology
  • Cardiology
  • Vasculitis Research

Background:

  • Kawasaki disease (KD) is an acute febrile vasculitis affecting children, primarily targeting coronary arteries.
  • Incomplete KD presents with fever but lacks sufficient diagnostic criteria, often leading to delayed diagnosis.
  • Coronary artery aneurysm formation is a significant complication of untreated KD.

Observation:

  • A one-and-a-half-year-old girl presented with high-grade fever, irritability, conjunctivitis, and cracked lips, suggestive of incomplete KD.
  • Laboratory findings included elevated platelet count (902 x 10^9/L), ESR (71 mm/hr), and CRP (12.8 mg/L).
  • Cardiac evaluation revealed dilated coronary arteries with early aneurysmal changes (left >3mm, right 4mm).

Findings:

  • The patient met the criteria for incomplete Kawasaki disease based on clinical presentation and investigations.
  • Diagnostic imaging confirmed coronary artery dilation and early aneurysmal changes, indicating significant vascular inflammation.
  • Prompt treatment with intravenous immunoglobulin and aspirin was initiated.

Implications:

  • This case underscores the importance of recognizing subtle signs of incomplete Kawasaki disease in pediatric patients.
  • Timely diagnosis and treatment are crucial to prevent severe cardiac sequelae, such as coronary artery aneurysms.
  • Aggressive management can lead to favorable outcomes and resolution of inflammatory processes in KD.