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Updated: Jun 25, 2026

Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction
Published on: August 9, 2022
Chronic total left main coronary artery occlusion.
Ayaz Hussain Shaikh1, Muhammad Adnan Amin, Bashir Hanif
1Department of Cartiology. Tabba Heart Institute, Karachi.
A 65-year-old smoker with shortness of breath had severe mitral regurgitation and an occluded left main coronary artery. Urgent surgery combining mitral valve replacement and aortocoronary bypass was required.
Area of Science:
- Cardiology
- Cardiovascular Surgery
Background:
- A 65-year-old male smoker presented with exertional dyspnea.
- Symptoms included jugular venous distension and basal crackles, responsive to diuretics and nitrates.
Observation:
- Echocardiogram revealed global left ventricular hypokinesis and severe mitral regurgitation.
- Diagnostic angiography showed a completely occluded left main coronary artery.
Findings:
- The left coronary system was supplied via collateral circulation from the right coronary artery.
- The patient required urgent combined surgical intervention.
Implications:
- This case highlights the importance of comprehensive pre-operative assessment in complex cardiac cases.
- Successful management necessitates a multi-disciplinary approach involving cardiology and cardiac surgery for optimal patient outcomes.
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