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Updated: Jun 25, 2026
Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
High-dose-rate interstitial brachytherapy for previously untreated cervical carcinoma
Fumiaki Isohashi1, Yasuo Yoshioka1, Masahiko Koizumi1
1Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan.
Purpose:
The aim of the study was to evaluate the results of high-dose-rate interstitial brachytherapy (HDR-ISBT) for patients with advanced cervical carcinoma in which intracavitary radiation therapy may result in a suboptimal dose distribution.
Methods And Materials:
Between 1995 and 2005, 25 patients of median age 64 years were treated with external beam radiation therapy and HDR-ISBT. The International Federation of Gynecology and Obstetrics stages of the patients were I (4%), II (16%), III (68%), and IVA (12%). Whole pelvic irradiation of 30Gy/15 fractions was followed by HDR-ISBT of 30Gy/5 fractions/3 days. Subsequently, additional pelvic external beam radiation therapy of 20Gy/10 fractions was delivered with a midline block. The median followup period was 55 months.
Results:
The actuarial 5-year progression-free survival and overall survival rates for all cases were 42% and 54%, respectively. For the 17 patients with a Stage III tumor, the 5-year local control and overall survival rates were 73% and 51%, respectively. Two patients (8%) developed late toxicities of Grade 3.
Conclusions:
A high rate of pelvic control and survival with acceptable level of late toxicities were obtained for patients with advanced cervical carcinoma treated with HDR-ISBT.
