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T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...

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Related Experiment Video

Updated: Jun 25, 2026

Isolation of Double Negative αβ T Cells from the Kidney
06:56

Isolation of Double Negative αβ T Cells from the Kidney

Published on: May 16, 2014

Lupus and T cells.

A La Cava1

  • 1Division of Rheumatology, Department of Medicine, University of California, Los Angeles, California, USA. alacava@mednet.ucla.edu

Lupus
|February 14, 2009
PubMed
Summary
This summary is machine-generated.

T-cell abnormalities contribute to immune system dysfunction in systemic lupus erythematosus (SLE). This review explores T-cell roles and emerging therapies targeting T cells to restore immune balance in SLE patients.

More Related Videos

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Related Experiment Videos

Last Updated: Jun 25, 2026

Isolation of Double Negative αβ T Cells from the Kidney
06:56

Isolation of Double Negative αβ T Cells from the Kidney

Published on: May 16, 2014

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Area of Science:

  • Immunology
  • Rheumatology
  • Cellular Biology

Background:

  • T-cell abnormalities and skewed T helper cytokine profiles are implicated in the loss of immune tolerance in systemic lupus erythematosus (SLE).
  • These immune dysregulations are linked to diverse clinical manifestations observed in SLE patients.

Purpose of the Study:

  • To review the critical role of T cells in the pathogenesis and progression of SLE.
  • To discuss the cellular and molecular abnormalities of T cells in SLE.
  • To provide an update on novel T cell-targeted therapeutic strategies for SLE.

Main Methods:

  • Literature review of existing research on T cells in SLE.
  • Analysis of cellular and molecular abnormalities in T cells relevant to SLE.
  • Synthesis of recent findings on T cell-targeted therapies for SLE.

Main Results:

  • T cells play a central role in promoting and maintaining immune tolerance loss in SLE.
  • Specific cellular and molecular defects in T cells drive SLE pathogenesis.
  • Emerging therapies focus on restoring T cell homeostasis.

Conclusions:

  • Understanding T-cell abnormalities is crucial for SLE pathogenesis.
  • Targeting T cells offers promising therapeutic avenues for SLE.
  • Restoring T cell balance is a key goal for SLE treatment.