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Published on: October 27, 2020

Bioinformatic and functional analysis of TGFBR1 polymorphisms.

Markus A Schirmer1, Arne O Hoffmann, Radu Campean

  • 1Department of Clinical Pharmacology, University Medicine Göttingen, Georg-August-University, Göttingen, Germany. mschirmer@med.uni-goettingen.de

Pharmacogenetics and Genomics
|February 14, 2009
PubMed
Summary

Genetic variations in the transforming growth factor-beta receptor 1 (TGFBR1), specifically the *6A deletion, may alter cellular responses to TGFB1 and increase sensitivity to radiation. These findings have implications for cancer susceptibility and treatment side effects.

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