Related Experiment Video
Updated: Jun 25, 2026

06:59
In Vivo Evaluation of the Mechanical and Viscoelastic Properties of the Rat Tongue
Published on: July 6, 2017
Cranial nerve XII: the hypoglossal nerve
1Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA. hlin@mcw.edu
Seminars in Neurology
|February 14, 2009
Summary
The hypoglossal nerve controls tongue movement and can be impacted by various conditions. Understanding its anatomy and performing thorough tongue examinations are crucial for diagnosing and managing related neurological disorders.
Area of Science:
- Neurology
- Anatomy
- Physiology
Background:
- The hypoglossal nerve (CN XII) is essential for motor control of the tongue.
- Pathology affecting the hypoglossal nerve can occur at numerous anatomical sites.
- Accurate diagnosis relies on understanding the nerve's pathway and tongue examination.
Purpose of the Study:
- To review the anatomy and physiology of the hypoglossal nerve.
- To discuss clinical disorders involving the hypoglossal nerve.
- To outline the evaluation methods for hypoglossal nerve dysfunction.
Main Methods:
- Literature review of anatomical and clinical studies.
- Synthesis of information on hypoglossal nerve function and pathology.
- Description of diagnostic approaches and examination techniques.
Main Results:
- Detailed anatomical course of the hypoglossal nerve described.
- Common and rare clinical conditions affecting the nerve identified.
- Systematic approach to clinical evaluation presented.
Conclusions:
- Comprehensive knowledge of hypoglossal nerve anatomy is vital for localization of lesions.
- Clinical examination of the tongue is a key diagnostic tool.
- Understanding the nerve's pathway aids in appropriate testing and management.
Related Concept Videos
Cranial Nerves: Types Part II
Cranial nerves are responsible for transmitting motor and sensory information between the brain and various parts of the body. There are twelve pairs of cranial nerves. While the first six innervate the head and neck, the latter six nerves innervate the head and neck, as well as organs and tissues in the thoracic and abdominal cavities. They facilitate communication, expression, and autonomic control within the human body.
Facial Nerve (Cranial Nerve VII)
Cranial nerve VII, or the facial nerve,...
Facial Nerve (Cranial Nerve VII)
Cranial nerve VII, or the facial nerve,...
Cranial Nerves: Overview and Anatomy
The cranial nerves are an important part of the complex network of nerves in the human body. These nerves emerge directly from the brain and are responsible for transmitting essential information between the brain and various parts of the head and neck. There are 12 pairs of cranial nerves, systematically numbered using Roman numerals from I to XII, beginning from the anterior and moving to the posterior of the brain. Each cranial nerve is uniquely identified by names that reflect its function...
Cranial Nerves: Types Part I
Cranial nerves are responsible for transmitting motor and sensory information between the brain and various parts of the body. There are twelve pairs of cranial nerves, with the first six being essential in sensory perception, motor control, and autonomic functions related to the head and neck.
Olfactory Nerve (Cranial Nerve I)
The olfactory nerve, or cranial nerve I, is unique as it is purely sensory and dedicated to the sense of smell. This nerve originates in the olfactory epithelium of the...
Olfactory Nerve (Cranial Nerve I)
The olfactory nerve, or cranial nerve I, is unique as it is purely sensory and dedicated to the sense of smell. This nerve originates in the olfactory epithelium of the...
Cranial Part of Parasympathetic Division
The cranial part of the parasympathetic division plays a crucial role in regulating the visceral functions of the head and specific structures in the neck, thoracic, and abdominopelvic cavities. Preganglionic fibers of the parasympathetic division exit the brain through cranial nerves III (oculomotor), VII (facial), IX (glossopharyngeal), and X (vagus), delivering parasympathetic output to the respective visceral structures.
The vagus nerve (cranial nerve X) alone accounts for approximately 75...
The vagus nerve (cranial nerve X) alone accounts for approximately 75...
Brainstem
The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
The Hyoid Bone
The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not directly articulate with any other bone in the body. The hyoid acts as the attachment site for the tongue, the larynx, and the pharynx. It is held in position by a series of small muscles attached from above or below. These muscles help to move the hyoid up/down or forward/back in coordination with movements of the tongue, larynx, and pharynx...

