Related Experiment Video
Updated: Jun 25, 2026

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Published on: August 20, 2018
Preparation and conformational analysis of C-glycosyl beta(2)- and beta/beta(2)-peptides
Yoko Inaba1, Toru Kawakami, Saburo Aimoto
1Department of Interdisciplinary Materials Science, Nara Women's University, Nara 630-8506, Japan.
Abstract:
Ten C-glycosyl beta(2)- and beta/beta(2)-peptides with three to eight amino acid residues have been prepared. Solution and solid-phase peptide syntheses were employed to assemble beta(2)-amino acids in which C-glycosylic substituents are attached to the C-2 position of beta-amino acids. Conformational analysis of the C-glycosyl beta(2)-peptides using NMR and CD spectra indicates that the tripeptide can form a helical secondary structure. Besides, helix directions of the C-glycosyl beta/beta(2)-peptides are governed by the configuration at the alpha-carbon of the peptide backbone that originates from the stereocenter of the C-glycosyl beta(2)-amino acids.
Related Concept Videos
Protein Folding Quality Check in the RER
Protein Folding
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
Peptidoglycan Synthesis
Protein Glycosylation
Glycosylation occurs in...
Peptide Bonds
Proteoglycans

