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Antiproliferative effects of peracetylated naphthoxylosides
Ulrika Nilsson1, Mårten Jacobsson, Richard Johnsson
1Organic Chemistry, Lund University, PO Box 124, SE-221 00 Lund, Sweden.
Bioorganic & Medicinal Chemistry Letters
|February 17, 2009
Abstract:
The antiproliferative activity, and the capability of priming of glycosaminoglycan chains, of two series of peracetylated mono- and bis-xylosylated dihydroxynaphthalenes have been investigated for normal HFL-1 cells, as well as transformed T24 cells, and compared to the unprotected analogs. Our data show increased antiproliferative activity upon peracetylation, but a loss of selectivity towards T24 cells.