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Structural basis of m(7)GpppG binding to poly(A)-specific ribonuclease.

Mousheng Wu1, Per Nilsson, Niklas Henriksson

  • 1Institute of Molecular and Cell Biology, Proteos, Singapore; Department of Biological Sciences, National University of Singapore, Singapore.

Structure (London, England : 1993)
|February 17, 2009
PubMed
Summary

Poly(A)-specific ribonuclease (PARN) degrades mRNA poly(A) tails. Structural studies reveal its cap-binding site overlaps the active site, crucial for deadenylation and mRNA regulation.

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