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Updated: Jun 25, 2026

Analyzing Synaptic Modulation of Drosophila melanogaster Photoreceptors after Exposure to Prolonged Light
Published on: February 10, 2017
Abstract:
In the developing retina the nuclear hormone receptor Nr2e3 has dual roles, promoting expression of rod-specific genes and repressing expression of cone specific genes. In a recent issue of Neuron, Onishi et al. show that PIAS3-mediated SUMOylation of Nr2e3 plays an essential role in the specification of rod photoreceptors by converting Nr2e3 to a potent repressor of cone gene expression.
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