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Updated: Jun 25, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Lowering low-density lipoprotein cholesterol: statins, ezetimibe, bile acid sequestrants, and combinations:
Runhua Hou1, Anne Carol Goldberg
1Endocrine Unit, University of Rochester, 601 Elmwood Avenue, Box 693, Rochester, NY 14642, USA.
Abstract:
Statins, ezetimibe, and bile acid-binding resins can be used individually or in combination for lowering low-density lipoprotein cholesterol (LDL-C) levels. Statins are the most potent drugs for lowering LDL-C and are well tolerated in most patients. The addition of a bile acid sequestrant or ezetimibe to a statin produces additional LDL-C reduction allowing many patients to reach LDL-C targets. This article discusses the efficacy and safety of available statins, bile acid sequestrants, and ezetimibe in the treatment of hyperlipidemia.
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