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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
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Uveal Melanoma Metastasis to the Thyroid
Rokshana R Thanadar1, Uzma M Siddiqui2, Shi Bai3
1Endocrinology and Diabetes Center of Tidewater, 3205 Churchland Blvd, Chesapeake, VA 23321, USA.
Case Reports in Endocrinology
|August 25, 2023
Summary
Thyroid metastasis from uveal melanoma is rare. This case highlights the importance of considering metastatic melanoma in thyroid nodules, especially with a history of ocular melanoma, necessitating immunohistochemistry for accurate diagnosis.
Area of Science:
- Oncology
- Ophthalmology
- Endocrinology
Background:
- Thyroid malignancies are rarely metastatic, with melanoma accounting for a small percentage.
- Uveal melanoma metastasis to the thyroid is exceptionally uncommon, with few reported cases.
Observation:
- An 86-year-old female with choroidal melanoma developed a goiter three months after ocular treatment.
- Thyroid ultrasound revealed multiple vascularized nodules.
- Fine needle aspiration (FNA) yielded indeterminate or nondiagnostic results initially.
Findings:
- Repeated FNA and subsequent immunohistochemistry confirmed metastatic malignant melanoma in the thyroid nodule.
- The patient's history of uveal melanoma was crucial for diagnosis.
Implications:
- Thyroid nodules in patients with uveal melanoma should be evaluated for metastasis.
- Immunohistochemistry is vital for diagnosing metastatic melanoma in thyroid FNA samples.
- This case underscores the need for a high index of suspicion in diagnosing rare metastatic patterns.
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