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Updated: Jul 14, 2026
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Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
Published on: March 17, 2023
Femtosecond Laser-Fabricated Bowl-Shaped Surface-Enhanced Raman Scattering Platform for Multibiomarker Analysis of
Mingyang Han1, Xiao Yang1, Rui Guo1
1Hebei Key Laboratory of Materials Near-Net-Forming Technology, School of Material Science and Engineering, Hebei University of Science and Technology, Shijiazhuang, Hebei, China.
Small Methods
|July 13, 2026
Summary
This study introduces a novel SERS substrate for early acute myocarditis (AM) detection. The high-performance platform enables sensitive biomarker quantification for noninvasive diagnosis.
Area of Science:
- Nanotechnology
- Biomedical Engineering
- Analytical Chemistry
Background:
- Early diagnosis of acute myocarditis (AM) is crucial but challenging due to ultralow biomarker concentrations.
- Existing diagnostic methods often struggle with sensitivity for early-stage detection.
Purpose of the Study:
- To develop a high-performance surface-enhanced Raman scattering (SERS) substrate for sensitive detection of AM biomarkers.
- To enable early, noninvasive diagnosis of acute myocarditis.
Main Methods:
- Fabrication of a novel bowl-shaped AuNP@SiO2 substrate using hydrofluoric acid etching and laser reshaping.
- Synthesis and characterization of gold nanoparticles (AuNPs) on SiO2 microbowls.
- Evaluation of SERS performance using Rhodamine 6G and AM biomarkers.
- Development of a fuzzy logic model for quantitative biomarker analysis.
Main Results:
- The novel SERS substrate achieved an enhancement factor of 10^6 and a limit of detection of 3.84 × 10^-8 M for Rhodamine 6G.
- Limits of detection for AM biomarkers were below 6 pg/mL, allowing for trace quantity detection.
- A fuzzy logic model demonstrated accurate quantitative analysis of biomarkers with a mean relative error < 25.7%.
Conclusions:
- The developed bowl-shaped SERS platform offers high sensitivity and reliability for detecting AM biomarkers.
- This technology facilitates early, noninvasive diagnosis of acute myocarditis.
- The SERS platform shows significant potential for clinical application in cardiovascular disease diagnostics.
