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Related Concept Videos

Inhaled Medications01:23

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation

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Related Experiment Video

Updated: Jun 25, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Systemic treatment by inhalation of macromolecules--principles, problems, and examples.

R Siekmeier1, G Scheuch

  • 1Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany. r.siekmeier@bfarm.de

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
|February 17, 2009
PubMed
Summary

Inhaled aerosol therapy for systemic diseases is now accurate and efficient thanks to modern delivery systems. This non-invasive method offers a viable alternative to injections for various medications.

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Area of Science:

  • Pulmonary Medicine
  • Pharmacology
  • Biotechnology

Background:

  • Aerosol inhalation is a standard treatment for lung diseases.
  • Its use for systemic diseases was limited by dose accuracy, efficiency, and reproducibility issues.
  • Previous challenges included low drug delivery to the lungs and potential respiratory allergic reactions.

Purpose of the Study:

  • To review the mechanisms of pulmonary absorption for macromolecules.
  • To provide an overview of research on inhaled systemic disease treatments.
  • To highlight advancements in aerosol therapy for systemic conditions.

Main Methods:

  • Summarizing mechanisms of pulmonary absorption of macromolecules.
  • Reviewing prior research on inhalant treatment of systemic diseases.
  • Analyzing the impact of modern aerosol delivery systems.

Main Results:

  • Modern aerosol systems have overcome previous limitations in dose accuracy and efficiency.
  • Allergic reactions were not observed in numerous studies with systemically active drugs.
  • Controlled aerosol therapy is a non-invasive alternative to syringe-based drug delivery for macromolecules like insulin and heparin.

Conclusions:

  • Advanced aerosol technology enables precise and effective systemic drug delivery via inhalation.
  • Pulmonary absorption of macromolecules is feasible and safe for treating systemic diseases.
  • Inhaled therapy presents a promising non-invasive alternative to traditional injection methods.