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Updated: Jun 25, 2026

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
Published on: June 15, 2020
Biventricular noncompaction associated with left ventricular systolic and diastolic dysfunction and severe pulmonary
Michal Ciurzynski1, Barbara Lichodziejewska, Andrzej Tomaszewski
1Department of Internal Medicine and Cardiology, Medical University of Warsaw, Warsaw, Lindleya 4, Poland. mciurzyn@amwaw.edu.pl
Abstract:
Noncompaction of the ventricular myocardium is a recently recognized genetic cardiomyopathy. The left ventricle is the most affected site, but right ventricular involvement has been reported in some cases. Diagnosis is made with 2-dimensional echocardiography or cardiac magnetic resonance imaging. The major clinical manifestations are heart failure, arrhythmias and embolic events. A 20-year old man had left and right ventricular noncompaction complicated by severe pulmonary hypertension, which is one of the first cases of biventricular noncompaction associated with severe pulmonary hypertension. Pulmonary hypertension may be a consequence of increased pulmonary venous pressures caused by systolic and diastolic heart dysfunction secondary to noncompaction.
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